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Acetylcarnitine, on the other hand, affects the epigenetic regulation of metabotropic glutamate type 2 receptors (mGluR2), negatively modulating neurotransmitter release and producing rapid and long-lasting antidepressant effects (demonstrated by forced swim tests, sucrose preference tests) in Flinders Sensitive Line rats and in mice exposed to chronic unpredictable stress, which model genetic and environmentally induced depression, respectively [92]

*Correspondence: Virendra Kumar Yadav, [email protected]

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Research Context & Areas of Scientific Interest In laboratory and preclinical settings, GHK-Cu has been studied for its involvement in: Copper-mediated biochemical pathways Cellular signaling and regulatory mechanisms Gene expression models in controlled environments Extracellular matrix interaction dynamics Molecular modeling involving peptide-metal complexes Cellular response behavior in in-vitro systems These observations originate from preclinical and laboratory research only and do not represent clinical or cosmetic effects in humans