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Why this matters -This is one of the largest retrospective cohort studies to date investigating this association, drawing from over 1.2 million beneficiaries

Further studies revealed that treatment with N-acetylcysteine (NAC), a GSH precursor, significantly upregulates the GSH/GSSG ratio and increases the expression of GPX4, NRF2, and HO-1, effectively inhibiting ferroptosis (Zhang S

Several pathways seem to be responsible for avoiding dysbiosis

Through ROS-mediated phosphorylation of IB kinase, NF-B is released from its inhibitor and translocates to the nucleus, where it induces transcription of pro-inflammatory cytokines, chemokines, adhesion molecules, and iNOS itself