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HGH at higher doses is associated with joint pain, significant fluid retention, insulin resistance, and potential organ enlargement with chronic supraphysiological exposure

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PKC-dependent phosphorylation enhances NMDAR function, reduces magnesium blocks, and promotes NMDAR trafficking to the plasma membrane, further strengthening synaptic activity (Xie et al., 2016)

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Specifically, the infralimbic (IL) and prelimbic (PL) regions of the PFC modulate fear extinction, with IL activation shown to facilitate this process in animal models

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