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Collectively, Oral HS lipo undergoes reversible, pH-triggered structural transitions: condensing into a protective aggregated state under acidic conditions and redistributing into discrete liposomes under neutral conditions

However, in patients with underlying arrhythmia or structural heart disease, GLP-1 therapy can unmask or exacerbate existing rhythm abnormalities that require management

20 In adolescents with obesity, semaglutide 2.4 mg once weekly resulted in similar weight loss to that seen in adults (16.1% mean change in body mass index from baseline vs 0.6% with placebo) at 68 weeks with improvement in cardiometabolic risk factors (i.e