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Description

Other additions to Category 1 include ruxolitinib phosphate, a JAK1and JAK2 inhibitor currently commercially available orally and topically for conditions such as myelofibrosis or atopic dermatitis respectively and dimercaprol,a chelating drug currently commercially-available as an injectable

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Inhibition of GNMT is achieved by SAM induced allosteric inhibition of 5,10-methylene tetrahydrofolate reductase (MTHFR) with concomitant decreased levels of 5-methyl-THF [2]

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