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A health care provider should help patients determine if these medications are appropriate for them

Both are GLP-1 receptor agonists initially developed for type 2 diabetes management but have shown significant benefits in weight reduction

It is well known that increased glutamate levels are associated with increased neuronal activity, leading to glutamate-induced excitotoxicity via reactive oxygen species (ROS) production [65, 66]

This concept is powerfully substantiated by a comprehensive meta-analysis encompassing seven major CVOTs, which concluded that the elevated risk of DR progression associated with semaglutide was driven by the magnitude and rapidity of HbA1c reduction, rather than a direct drug effect [86]