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The Fund may be susceptible to an increased risk of loss, including losses due to adverse events that affect the Funds investments more than the market as a whole, to the extent that the Funds investments are concentrated in the securities and/or other assets of a particular issuer or issuers, country, group of countries, region, market, industry, group of industries, sector, market segment or asset class

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For drugs like Stelara (ustekinumab, Johnson & Johnson), which faced biosimilar entry beginning in 2023 in the U.S., and Eylea (aflibercept, Regeneron), where biosimilar entry occurred in 2024, the Humira retention data provides a more accurate revenue tail model than historical small molecule LOE curves

Mechanical overload and energy storage demand: High-repetition loading (running, jumping) stresses the tendons spring-like function