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10.1080/10550490490436055 Summary Keywords methamphetamine, cocaine, synthetic cathinones, ketamine, nitrous oxide, heroin, nervous system damage Citation Wang J, Hao Y, Ma D, Feng L, Yang F, An P, Su X and Feng J (2025) Neurotoxicity mechanisms and clinical implications of six common recreational drugs

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The mix already works through two powerful mechanisms (GLP-1 and amylin receptor start) and produces near-maximal weight loss effects, so adding more peptides may not provide major more benefits and could increase side effects