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The semaglutide product approved for weight management is Wegovy, which is indicated in combination with a reduced-calorie diet and increased physical activity to reduce excess body weight and maintain weight reduction long term in adults and pediatric patients aged 12 and older with obesity, and in adults with overweight plus at least one weight-related comorbid condition

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47,48 For instance, the degree of HRV reduction, together with abnormal EEG microstate patterns, could help distinguish between ANS-dominant and central sensitization subtypes of NERD, thereby providing a rationale for individualized treatment