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Dopamine is a neurotransmitter that plays a crucial role in coordinating smooth and controlled muscle movements [88, 89]

Monitor cognition and brain health : If using GLP-1 agents, baseline cognitive testing (memory, executive function) and periodic follow-up may help document whether there is slowing of decline (though in routine practice, this is limited)

Within this framework, mitochondria are best understood as central interaction hubs for the ER, lysosomes, inflammasome platforms, and other organelles in PACs

The findings were reassuring enough that, in January 2026, the Food and Drug Administration (FDA) requested the removal of suicidal ideation and behavior warnings from the labels of GLP-1s, including Wegovy and Zepbound, after reviewing the available evidence