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The rationale offered for the blend is intuitive: pair a collagen-and-matrix stimulator (GHK-Cu), two broad-spectrum healing peptides that promote angiogenesis and cell migration (BPC-157 and TB-500), and an anti-inflammatory tripeptide (KPV), and you cover the major phases of tissue repair inflammation control, angiogenesis, cell recruitment, and matrix synthesis in a single injection

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In addition, residual confounding and reverse causality present in traditional observational studies pose challenges in quantifying causal effects