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The cyclin-dependent kinase 5 (Cdk5), a proline-directed S/T kinase, was demonstrated to mediate basal and morphine-activated DOR phosphorylation at the T161 located in the second intracellular loop (Xie et al., 2009)

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DHT, a more potent androgen, is converted from testosterone by 5 -reductase isozymes, and is the major intracellular androgen and the major mediator of androgen action in the prostate cells

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