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This positions postbiotics as context modulators that complement established lean masspreserving interventions rather than substitutes for them ( Although postbiotics are not expected to exert direct anabolic effects on skeletal muscle, their potential relevance to lean mass preservation lies in indirect metabolic pathways

Typically, treatment begins with a lower dose to minimize side effects, gradually increasing over time until achieving a maintenance dosage

Inhibition of MetAP2 reduced fibroblast proliferation and collagen deposition in BLM-treated mice, indicating its potential as a pro-fibrotic mediator [127, 128]

However, there may be an adjustment period when starting a new supplement