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Many patients experience weight loss without significant nausea, while others have moderate symptoms that diminish quickly

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This introduces clinical heterogeneity and considerably attenuates the practical interpretation of pooled estimates, given the well-established beneficial effects of GLP-1 RAs in reducing both HbA 1c and body weight, as opposed to the neutral effect of a placebo intervention [4,5,6]

The MHRA ( Medicines and Healthcare products Regulatory Agency ) has two main application procedures: Simple Reclassification : This is a straightforward and quick procedure based on an analogous product (a medicinal product already on the UK market with the same active ingredient, route of administration, use, and a similar or higher strength/dosage)