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Moreover, the KEGG pathways associated with these core target genes included neutrophil extracellular trap formation, longevity regulating pathway, riboflavin metabolism, AGE-RAGE signaling pathway in diabetic complications, sphingolipid signaling pathway, p53 signaling pathway, HIF-1 signaling pathway (Fig

However, for patients with sensitive gastrointestinal tracts or MCAS, standard high-dose Vitamin C supplements can sometimes cause more harm than good, triggering acid reflux, stomach upset, or even histamine release if derived from citrus