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In a phase 2b trial, cotadutide reduced glycemia and body weight and improved metabolic-dysfunction associated steatotic liver disease (MASLD) 18

Contrave is a medication that acts to alter [the] brain signal (dopamine pathway) in the part of the brain (hypothalamus) responsible for controlling how hungry we feel and how much energy we burn, as well as in the part of the brain (mesolimbic system) that controls how much pleasure we feel while eating certain foods and how compulsive we feel in repeatedly seeking the same pleasure, Muzamil Hussain, PhD, a clinical research fellow diabetes and obesity at Ulster University in the United Kingdom, and co-author of this study, told Medical News Today