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Un equipo internacional de investigadores de China, Canad y varios pases europeos publica en The British Medical Journal (BMJ) una revisin sistemtica y un metaanlisis en red que rene los resultados de 262 ensayos clnicos aleatorizados con cerca de 100.000 participantes y compara 19 tratamientos farmacolgicos para la obesidad, tanto ya comercializados como en desarrollo con seguimientos de entre 12 y 172 semanas

[20] The athletes, who were given 10 g per day of D-ribose during high intensity training, showed significant improvements in performance and reduced levels of the muscle damage marker creatine kinase (CK), with a lowered perceived exertion reported on the part of the test participants

DOI: 10.1016/S0169-409X(96)00423-1 Llompart, P

As in other publications, the reasons for switching were failure to meet individual HbA1c or weight targets, improve cardiovascular status, improve adherence (once weekly vs