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Quickstart Highlights IGF-1 LR3 (Long-Arg3 Insulin-like Growth Factor-1) is a modified analog of human IGF-1 with much-reduced affinity for IGF binding proteins, giving it a substantially longer half-life and prolonged receptor activity [1] [2]

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This landmark direct-comparison trial confirmed that tirzepatide produced approximately 47% greater body weight reduction than semaglutide in adults with obesity over a comparable treatment period the first robust head-to-head evidence in patients without type 2 diabetes