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and Jacob Whitsitt, MD KSDDS Newsletter Educational Coordinator - Demi Elrod (UMKC - SOM) Abbreviations used: HHV-8: human herpesvirus 8 JAK: Janus kinase KS: Kaposi sarcoma MSM: men-who-have-sex-with-men UC: ulcerative colitis Introduction Kaposi sarcoma (KS) is a rare neoplasm of lymphatic endothelium-derived cells infected with human herpesvirus 8 (HHV-8).1 There are 4 variant forms of KS: classic, AIDS-related, endemic (African), and iatrogenic.1 Recent literature has noted an emerging fifth variant of KS seen in men-whohave-sex-with-men (MSM) but who are HIV-seronegative.2 With the growing use of immune modulating medications such as Janus kinase (JAK) inhibitors for a range of inflammatory diseases, there have been an increasing number of reported iatrogenic KS cases associated with these medications.3 We report a case of KS in a patient who is MSM with a history of severe ulcerative colitis (UC) treated with upadacitinib, highlighting both the potential risk of malignancy associated with JAK inhibitors and risk of KS in MSM patients without HIV

These metabolic effects are closely tied to reproductive health

Melanotan I Peptide Details Melanotan 1 (MT1) is a synthetic linear analog of alpha-melanocyte-stimulating hormone (-MSH) with the peptide sequence Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH

Thats why it is important to talk to your physician before self diagnosing