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Wilson [86] further established that the degree of fatty infiltration can act as a biomarker for chronic rotator cuff injuries, with elderly and female patients being more prone to this phenomenon

Indeed, patients carrying the G allele of the IGF-1R rs2016347 polymorphism have poorer prognosis compared with those carrying G/T or T/T and has been associated with increased risk of tumor progression and death [78]

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However, across many checkpoint-focused AD studies that primarily target oxidative stress, A clearance, or neuroinflammatory checkpoints, the field has only rarely measured a complete ferroptosis signaturethat is, simultaneous assessment of iron-dependent lipid peroxidation together with GPX4/SLC7A11 and ACSL4/LPCAT3 alterations, combined with ferroptosis-selective rescue experiments (e.g., ferrostatin-1, liproxstatin-1, or FSP1 activation)