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PMID: 34532928

The Abdool Karims have saved lives around the globe through their innovative research, evidence-based policy proposals, public education, and courage to speak truth to power, the foundation said.

Safety Considerations and Future Outlook As with all pharmacotherapy for obesity and T2D, establishing cardiovascular safety and demonstrating improvements in meaningful clinical outcomes will be essential, particularly as cardiovascular outcome trials have not yet been completed with multi-agonists (although data are expected soon for tirzepatide: SURPASS-CVOT [T2D] in 2025

The first two weeks typically bring improvements in sleep quality and recovery rather than scale changes, followed by subtle body composition shifts around week four