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Some people achieve their target weight loss at 5 mg or 10 mg and stay there as their maintenance dose

187 Therefore, EV miRNAs may play a dual role in the aging process: on the one hand, they stimulate cells and tissues to become more dynamic and delay aging, and on the other hand, they drive metabolic insufficiency to aggravate aging

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Importantly, FIH studies also provide essential information for the design of Phase 2 trials , including decisions related to dosing schedules, administration frequency and safety monitoring strategies