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Pharmacogenomics I148M VARIANT OF THE PNPLA3 GENE The I148M mutation of the PNPLA3 gene has been considered the main genetic factor related to susceptibility to MASH 61

Through semaglutide, many patients start seeing weight loss effects within 2-4 weeks, with optimal results often seen within 12-16 weeks

Conversely, the later gonadotropin-dependent stages, particularly antral follicle growth and dominance, are inhibited by the elevated concentrations of progesterone and estrogens produced by the corpora lutea and placentae (Driancourt et al., 2000