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Available from Accessed 23 July 2024 Ethics declarations Data availability The datasets presented in this article are not readily available due to legal restrictions on sharing the dataset as regulated by the Valencia regional government by means of legal resolution by the Valencia Health Agency [2009/13312] which forbids the dissemination of data to third parties (accessible at: Upon request, authors can allow access to the databases to verify the accuracy of the analysis or the reproducibility of the study

Gradual dose escalation can significantly mitigate the frequency and severity of symptoms such as nausea and diarrhea, as it allows patients to adapt to therapy over time (Huang et al., 2025

GLP-1 Mechanism and HS: What Clinical Evidence Shows GLP-1 receptor agonists activate GLP-1 receptors on immune cells and intestinal epithelial cells, reducing pro-inflammatory cytokine production and supporting intestinal barrier integrity