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Cell fate specification begins during preimplantation development with the critical segregation of inner cell mass (ICM) and trophectoderm (TE) lineages, representing the first cell fate decision in mammalian development
In a mouse model where skin fibrosis was induced by intracutaneous injections of TGF-1, MSH reduced the accumulation of SMA positive cells and collagen deposition (160)
Changes relative to baseline lean mass were similar between the groups, and meta-regression analysis indicated that reductions in total body weight were significantly associated with fat mass loss but not with lean mass
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