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Boosting BDNF: Curcumin reverses the decrease in BDNF levels from chronic stress.[ref] Rheumatoid Arthritis: Curcumin is beneficial in reducing inflammation in RA.[ref] IL-17 and Autoimmune Risk: Curcumin was found to decrease IL-17 (in an animal study).[ref] HMGB1 and Inflammasome activation: In animal studies, Curcumin inhibits HMGB1 release .[ref][ref] Osteoarthritis: A natural TNF-alpha blocker, curcumin has been shown in several studies to be effective for osteoarthritis.[ref][ref] A clinical trial found that curcumin (500mg / 3x per day) was as effective as diclofenac for osteoarthritis but with fewer side effects.[ref] MRGPRX2 receptor on Mast Cells: Curcumin is likely a MRGPRX2 receptor blocker (animal and cell studies).[ref] Full article and details on berberine Berberine is a natural supplement with some amazing research for reducing high blood glucose levels and high cholesterol

One important limitation: the clinical weight loss results were modest

The following evidence-backed recommendations help mitigate side effects while maximizing health outcomes: Lean Protein: Focuses on plant-based sources like tofu, edamame, and legumes to promote fullness and prevent the loss of lean muscle mass often associated with reduced caloric intake

If the power goes out, keep the medication in the refrigerator and avoid opening the door to maintain the cold temperature