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However, electrons may prematurely leak from complexes I, II, and III to mediate the one-electron reduction of oxygen to O 2 , which is then dismutated to H 2 O 2 (Fig

Indeed, the fact that administration of phenformin can induce lactic acidosis, while metformin does not, suggests that these two biguanides act through different pathways ( Various in vitro and in vivo studies performed in different types of tumors, highlighted the ability of phenformin to reduce cancer cell proliferation strongly than metformin (Janzer et al., 2014)