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Standard solutions of nitrates (NO 3 ), nitrites (NO 2 ) and hydrogen peroxide (H 2 O 2 ) were prepared in ranges of concentrations corresponding to their content in PTL up to the concentrations that, according to the literature 39,40,41 correspond to the minimum inhibitory concentrations (MIC)

Serum IgG and mucosal secretory IgA (sIgA) were detected with HRP-conjugated goat anti-mouse IgG and HRP-conjugated goat anti-mouse IgA (Jackson ImmunoResearch, USA), respectively

All subsequent daily doses are recommended to be in the range of 50 mg/kg or as therapy may require

NICE Clinical Knowledge Summaries and the British Society for Haematology advise that patients on warfarin should maintain a stable diet rather than avoiding vitamin K entirely, as erratic intake can cause dangerous fluctuations in their International Normalised Ratio (INR)