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By pairing the "demolition crew" (Adipotide) with the "cleanup combustion engine" (MOTS-c), the theoretical efficiency of processing and permanently removing body fat skyrockets

These proteins showed enrichment in GO_MF terms related to catalytic activity (299 proteins, 53%) ( p adjusted = 2.7E-14) and hydrolase activity ( p adjusted = 4.3E-14) (Supplementary Table S6

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Furthermore, in a phase II study, the combination of chemotherapy (albumin-bound paclitaxel and gemcitabine) along with pegvorhyaluronidase alfa (PEGPH20), an agent designed to degrade hyaluronan, has been shown to improve progression-free survival in pancreatic cancer patients, especially those with hyaluronan-high tumors [136]