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MOTS-c was found to upregulate key genes in the TGF-/Smad pathway (such as TGF-1, TGF-2, and Smad7) and increase the expression of bone formation markers like alkaline phosphatase (ALP), osteocalcin, and Runx2 in bone cells

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Additional conditions such as cubital tunnel syndrome (compression of the ulnar nerve at the elbow) and cervical radiculopathy are often suspected in conjunction with carpal tunnel syndrome, and these may be demonstrated with use of electrodiagnostic studies, further improving likelihood of successful treatment