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For many patients on lower maintenance doses, this single-day acceleration produces only mild symptoms like temporary appetite suppression or light nausea, but the risk increases as your dose climbs higher during your titration schedule

Tirzepatide is a dual agonist of GIP and GLP-1 receptors, acting in an integrated way across incretin pathways.It increases insulin secretion in a glucose-dependent manner and improves glycaemic regulation (reducing peaks and variability)

Cell Mol Life Sci 79(7):387 Jin DY et al (2023) A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase