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However, patients with renal impairment, elevated homocysteine, choline metabolism disorders, or those taking anticoagulants should discuss potential interactions with their provider before starting

While semaglutide addresses appetite regulation and metabolic signaling, green tea's modest thermogenic effect could theoretically support additional calorie expenditure during exercise

Third, the TRIUMPH-4 population (obesity plus knee OA) is slightly different from the STEP-1 and SURMOUNT-1 populations (general obesity), so the definitive head-to-head comparison waits for TRIUMPH-1

These findings should be interpreted with caution given the limited evidence base, imprecision of several estimates, and the observational nature of the included studies