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The test checks for two types of autoantibodies: Blocking autoantibodies (that BLOCK folate from getting into the cell) Binding autoantibodies (that clump together and therefore make it more difficult to adhere to the folate receptor.) This 2023 paper discusses the higher the binding autoantibodies, the better the response to leucovorin (prescription high-dose folinic acid)

While this mechanism contributes to weight loss and glycemic control, it can produce gastrointestinal symptoms and affect other aspects of patient care