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Semaglutide provides superior glycemic control across SUSTAIN 15 clinical trials

Studies show that patients who maintained reduced portion sizes, increased protein intake, and regular exercise during semaglutide therapy regain significantly less weight than those who relied entirely on medication effects

However, challenges may arise regarding orthogonality and chemoselectivity

Although we did not observe improvement in triacylglycerol levels, some authors report that increased incretin plasma concentration is related to the reduction of intestinal absorption of triacylglycerol in animal studies 34 , besides Vildagliptin be able to lowers triacylglycerol-rich lipoprotein postprandial levels in T2DM, suggesting that DPP-4 inhibitors mobilize and burn fat during meals, and thus the fat that is associated with cardiovascular risk is not accumulated 35