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discovered a reduced Paneth cell -defensin synthesis in ileal Crohn disease, a chronic disease of the intestine [186], and Ferguson et al

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F., Wang, Z., Lammerding, J., & King, M

In CRS mice, THC administration reversed anxiety- and depressive-like behaviors (open field, tail suspension, and forced swim tests), normalized prefrontal cortex (HSP90, KRT6A, P4HB, C1QA, APOM, CDH13) and hippocampal (HSP90, P4HB, CDH13) protein expression in mice, and restored serum levels of P4HB, C1QA, and CDH13 in both humans and mice, while additionally modulating LTF, TNF-, IL-1, cAMP, and DA in mice serum