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(4) Potential mechanisms may involve reduction of NF-B and MAP kinase signaling, and interactions with vasodilators like nitric oxide (NO), thereby possibly lowering pro-inflammatory cytokine output

To maintain weight loss, patients must sustain healthy diet and exercise habits developed during therapy

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Consistent with the finding that there is no apparent increase in enzymatic activity, the transcript levels of genes encoding -glutamylcysteine synthetases did not change significantly either