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A lack of MTFT induces mitophagy in osteoblasts through the ROS/PINK1/Parkin pathway to release iron, but excess the iron cannot be stored through the MTFT pathway, gradually accumulates and ultimately induces ferroptosis in osteoblasts [266]

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Functional brain imaging shows dysfunction in three major networks related to depression, including default mode network (DMN) responsible for resting taste introspection and ruminations, the salience network (SAL) processing salient information from external sources and the central network (CEN) responsible for working memory and attention (136)