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Description

Although more research is needed to fully elucidate this relationship, the findings are promising

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Early cognitive impairment during aging is mechanistically connected with elevated bioenergetic defects and a more oxidant state in the mitochondrial environment [85]

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Oxidative Stress and the Metal Ion Hypothesis: Different types of ROS interact with various metal valences (Iqbal et al., 2014), intensifying neuronal cell apoptosis and contributing to AD pathogenesis

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