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1 Symptoms of Hypoglycemia A reduction in blood glucose initiates an autonomic nervous system response, resulting in neurogenic signs and symptoms (categorized as adrenergic or cholinergic) that alert the patient to a hypoglycemic episode ( TABLE 2 )

| BioPharma Dive, accessed February 2, 2026, Trump Announces Deals With Lilly, Novo to Cut Weight Loss Drug Prices | AJMC, accessed February 2, 2026, Federal Update: Trump Administration Announces Deal to Bring Most-Favored-Nation Pricing to GLP-1s AMCP, accessed February 2, 2026, Eli Lilly, Novo Nordisk strike deals with White House to cut prices of weight loss drugs, accessed February 2, 2026, The GLP-1 Blockbuster Maker Widens Its Lead as the Diversified Healthcare Giant Posts Steady Growth, accessed February 2, 2026, Eli Lilly Stock Outlook: Fast-Track Oral GLP-1 Review Meets Long-Term Catalysts, accessed February 2, 2026, Beyond the Needle: Eli Lillys Orforglipron and the Small Molecule GLP-1 Revolution, accessed February 2, 2026, Patent and Innovation Trends in GLP-1 and Weight Loss Drugs (20202025): What the IP and Science Signal Next | Cypris, accessed February 2, 2026,

17,18,19 Semaglutide, a long-acting GLP-1RA with superior efficacy to older GLP-1RA medications, received FDA approval for diabetes in 2017 and obesity in 2021

Furthermore, inpatient and total costs were lower in Michigan than in Wisconsin ( Figure 4 )