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For example, ocrelizumab was associated with several cases of malignancy in clinical trials, including cases of renal cancer, melanoma, and breast cancers

Among currently available agents, GLP-1 RAs - and tirzepatide in particular, based on the SURMOUNT-1 subgroup analysis - have the most substantial weight-loss evidence in this population, with efficacy appearing comparable to that observed in common obesity

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In adolescents, were more likely to target treatment therapies based on if there are other risk factors such as diabetes, pre-diabetes or fatty liver," McCauley explained