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Oxidative stress damages skin cells, accelerates collagen breakdown and contributes to a dull, tired appearance particularly in patients with chronic UV exposure, frequent travel and disrupted sleep

Therefore, modulation of the I Na /I to relation has an important role in current clinical diagnostic risk stratification and therapeutic approaches in BrS, including (1) the application of sodium-channel blockers as a diagnostic test for inducibility of Brugada ECG (ajmaline or flecainide challenge) [26], (2) the use of quinidine to decrease arrhythmic burden in BrS patients by inhibiting I to [62], (3) the use of isoproterenol or other -adrenergic stimuli in arrhythmogenic storm to increase depolarizing current (in particular L-type calcium current

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