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Using melatonin has also been associated with decreased levels of malondialdehyde (MDA), the stable end product of lipid peroxidation and an indirect indicator of increased intracellular ROS generation

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Researchers suggest there is a chance it may boost the expression of the early growth response 1 gene, which may play a role in producing cytokines and growth stimuli, and possibly aid in the initial assembly of the extracellular framework, inclusive of collagen

This combined interpretation helps distinguish a primary disturbance in glutathione metabolism from a downstream response to broader cellular stress