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The authors propose here the new 5R principle, which considers the R ight species, R ight place, R ight time, R ight level, and R ight target. Erythrocytes are organelle-free cells that do not possess mitochondria and peroxisomes

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ROS exert cellular toxicity by modifying DNA, lipids, and proteins through DNA base oxidation, lipid peroxidation, and protein carbonylation (protein oxidation), respectively 7,8,9