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Low-grade systemic inflammationcharacterized by elevated levels of the cytokines interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and/or C-reactive protein (CRP)participates in the development of metabolic diseases such as heart disease, cancer, type II diabetes, and arthritis (Libby, 2007)

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Directly supplementing with oral reduced glutathione (L-GSH), however, presents a fundamental pharmacokinetic challenge: GSH has a plasma half-life of approximately 1.6 minutes, undergoes rapid hydrolysis in the gut by intestinal -glutamyl transpeptidase (-GT), and cannot cross cell membranes intact requiring full breakdown into constituent amino acids and intracellular resynthesis