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In the STEP-4 trial (N=803), patients who continued semaglutide 2.4 mg maintained their weight loss, while those who switched to placebo regained an average of 6.9% body weight over 48 weeks, underscoring that this is a chronic therapy rather than a short course

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Fratta Pasini et al., 2021), targeting Nrf2 is therefore essential for the treatment of diseases characterized by enhanced oxidative stress and inflammation, such as aging and COVID-19-induced pneumonia and ARDS (Lewis et al., 2010