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What we know from TRIUMPH-4 (blood pressure through 68 weeks): Systolic BP: -14.0 mmHg (12mg dose, efficacy estimand) Diastolic BP: -4.3 mmHg average reduction These reductions persisted even as weight loss plateaued in the final weeks, suggesting blood pressure benefits may be partially independent of weight possibly due to direct GLP-1 and glucagon receptor effects on vascular function

Despite these unknowns, TRIUMPH-4 has firmly established retatrutide as the most effective obesity medication in clinical development

A 5-unit error on a 100-unit injection represents 5% variation

GLP-1 medications like Wegovy arent a first step, says Heather Gosnell, MD, a pediatrician and plant-based health coach in Phoenix, Arizona