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Such are surmountable with particular chemical modifications including PEGylation, cholesterol conjugation, and circular nucleic acid, which enhance the stability of aptamers, improve pharmacokinetics, and prolong the circulation time

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509 Clinical evidence indicates that the expression of ER stress-related proteins such as IRE1, PERK, and CHOP is reduced in SLE patients, while the levels of XBP1 and midbrain astrocyte-derived neurotrophic factor (MANF) are elevated, suggesting their potential role in disease development

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