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biochemical markers provide a real-time phenotype of metabolic, infectious, hormonal, inflammatory and toxic states

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The LEAP randomised clinical trial 3 demonstrated that high success rates are possible when: the condition is well understood, patients are carefully screened with a battery of tests with established diagnostic utility and the intervention is well informed by evidence regarding pathoaetiological mechanisms and impairments

Understanding the interactions between metal ions, ROS signaling, and metabolic regulation can guide breeding and biotechnological approaches for developing metal-tolerant crops and ensuring sustainable agricultural production in contaminated soils