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The second most prevalent IGFBP is IGFBP-2, which has a growth inhibitory effect on healthy prostate epithelial cells but a strong stimulatory effect on prostate cancer cells via the activation of MAPK and PI3K pathways (146)

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Follow a good weight training program I encourage those with thyroid and/or adrenal dysfunction to use lower reps, and heavier weights a few times per week to build muscle, and slowly get their muscles to begin functioning better

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