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4648 Mechanistically, TMAO may induce T2DM by inducing pancreatic -cell dysfunction, chronic inflammation, oxidative stress, and disrupting glucose and lipid homeostasis

These risks are still being investigated but research suggests these drugs reduce gallbladder motility (emptying), alter the composition of bile (due to rapid weight loss), and lead to biliary stasis (bile sitting too long)all of which can contribute to gallstones and inflammation

That delay is why people often blame the wrong week, the wrong meal plan, or the wrong dose increase

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